Skin corrosion and irritation test of sunscreen nanoparticles using reconstructed 3D human skin model

Skin corrosion and irritation test of sunscreen nanoparticles using reconstructed 3D human skin model

OBJECTIVES Effects of nanoparticles including zinc oxide nanoparticles, titanium oxide nanoparticles, and their mixtures on skin corrosion and irritation were investigated by using in vitro 3D human skin models (KeraSkin ((TM)) ) and the results were compared to those of an in vivo animal test. METHODS Skin models were incubated with nanoparticles for a definite time period and cell viability...

Skin Corrosion and Irritation Test of Nanoparticles Using Reconstructed Three-Dimensional Human Skin Model, EpiDermTM

Effects of nanoparticles (NPs) on skin corrosion and irritation using three-dimensional human skin models were investigated based on the test guidelines of Organization for Economic Co-operation and Development (OECD TG431 and TG439). EpiDermTM skin was incubated with NPs including those harboring iron (FeNPs), aluminum oxide (AlNPs), titanium oxide (TNPs), and silver (AgNPs) for a defined time...

Skin irritation and corrosion.

Subgroup 2 . Skin Irritation / Corrosion

ECVAM, Institute for Health & Consumer Protection, European Commission Joint Research Centre, 21020 Ispra (VA), Italy; EVIC FRANCE,33290 Blanquefort, France; Syngenta, Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK; SEAC, Unilever Colworth Laboratory, Sharnbrook Bedfordshire MK44 1LQ,,UK; ZEBET BfR, Diedersdorfer Weg 1, 12277 Berlin, Germany; TNO Nutrition & F...

Review Articles in Vitro Safety Testing Strategy for Skin Irritation Using the 3d Reconstructed Human Epidermis

One of the most recent trends in skin irritation safety testing of personal care and cosmetic products, discussed in detail in this review, is the use of reconstructed human epidermis models. Some of the commercially-available models have undergone a series of validation trials, which successfully advanced them as valuable tools for industry use. On a broader perspective, the 3D models are now ...